Carcinoma of Breast (FN-02)


Specimen consists of a breast removed surgically showing dense bands of greyish tumour extending into the yellow adipose tissue and into the pectoral muscle (without obvious haemorrhage and necrosis). This is the feature of the classic (NOS) of breast cancer technically known as IDC of the schirrhous type.  The tumour extending into the pectoral muscle fixes the tumour to the chest wall, and is associated with a high grade tumour (poorer prognosis). Although the nipple appears to be retracted, and the skin is dimpled (peau d’orange), these features cannot be preserved in formalin-fixed tissue. Microscopically, the tumour is an infiltrating ductal adenocarcinoma.  The breast tissue also appears shrunken.

Core Learning Issues

Breast carcinoma - types, pathogenesis and etiology (risk factors);
Gross and microscopic features of common types (NOS or Schirrhous type);
Grading and staging of breast cancer;
Breast screening - characteristic appearance of carcnoma on mammography.

Self Assessment

  1. List steps in the pathogenesis of breast cancer from fibrocystic disease;
  2. Briefly describe the role of BRCA1 and BRCA2 gene in female malignancies;
  3. List three gorss and microscopic features in classic IDC (NOS);
  4. Briefly outline the microscopic features of Duct Carcinoma In-Situ (DCIS).